has_part has part has_part has disposition at some time attenuated disposition Brucella pth mutant B. abortus 2308 pth mutant YH The gene pth from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. PMID: 15385478 NCBIGene: 3788869 A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene pth. UniProtKB accession: Q2YLX5 Information about the mutated molecule: FUNCTION: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity)(Swiss-Prot: P65864). CATALYTIC ACTIVITY: N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA(Swiss-Prot: P65864). SUBUNIT: Monomer (By similarity)(Swiss-Prot: P65864). SUBCELLULAR LOCATION: Cytoplasm (By similarity)(Swiss-Prot: P65864). SIMILARITY: Belongs to the PTH family(Swiss-Prot: P65864). MUTATION: pth encodes for a peptidyl tRNA hydrolase. Transposon insertion in pth has a polar effect on dugA expression and that the pth/dugA mutant is deficient in iron assimilation because of altered expression of the dugA gene. Only minor difference in intracellular growth in bovine macrophages and HeLa cells between the pth/dugA mutant and wild-type strains was observed [Ref6498:Danese et al., 2004]. pth peptidyl-tRNA hydrolase