has_part has part has_part has disposition at some time attenuated disposition B. abortus purH mutant B. abortus 2308 purH mutant Information about the mutated molecule: CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(Swiss-Prot: P67540). CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(Swiss-Prot: P67540). PATHWAY: Nucleotide biosynthesis NCBIGene: 3788876 PMID: IMP biosynthesis The gene purH from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. UniProtKB accession: Q2YLH0 A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene purH. YH purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase