has_part has part has_part has disposition at some time attenuated disposition B. melitensis xseA mutant B. abortus 2308 xseA mutant UniProtKB accession: Q2YL15 PMID: 14638795 A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene xseA. YH The gene xseA from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. Information about the mutated molecule: FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)(Swiss-Prot: Q8FVR1). CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates(Swiss-Prot: Q8FVR1). SUBUNIT: Heterooligomer composed of large and small subunits (By similarity)(Swiss-Prot: Q8FVR1). SUBCELLULAR LOCATION: Cytoplasm (By similarity)(Swiss-Prot: Q8FVR1). SIMILARITY: Belongs to the xseA family(Swiss-Prot: Q8FVR1). MUTATION: xseA codes for an exodeoxyribonuclease. B. melitensis xseA mutant via signature-tagged mutagenesis is attenuated in vivo in mice [Ref6480:Lestrate et al., 2003]. NCBIGene: 3827916 xseA exodeoxyribonuclease VII large subunit