has_part has part has_part has disposition at some time attenuated disposition B.melitensis fliF mutant B. abortus 2308 fliF mutant A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene fliF. PMID: multi-pass membrane protein (By similarity)(Swiss-Prot: Q8FUS3). SIMILARITY: Belongs to the fliF family(Swiss-Prot: Q8FUS3). MUTATION: fliF is a gene potentially coding for the MS ring, a basal component of the flagellar system. Its mutant through signature- tagged mutagenesis is attenuated in vivo. It implicate a role for flagella in virulenc [Ref6480:Lestrate et al., 2003]. NCBIGene: 3828220 The gene fliF from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. Information about the mutated molecule: FUNCTION: The M ring may be actively involved in energy transduction (By similarity)(Swiss-Prot: Q8FUS3). SUBUNIT: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity)(Swiss-Prot: Q8FUS3). SUBCELLULAR LOCATION: Inner membrane YH UniProtKB accession: Q2YJF2 fliF flagellar MS-ring protein