has_part has part has_part has disposition at some time attenuated disposition Brucella gcvP mutant B. abortus 2308 gcvP mutant The gene gcvP from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene. NCBIGene: 3828233 UniProtKB accession: Q2YKX9 A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene gcvP. Information about the mutated molecule: FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor PMID: CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity)(Swiss-Prot: Q8FVU9). CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2)(Swiss-Prot: Q8FVU9). COFACTOR: Pyridoxal phosphate (By similarity)(Swiss-Prot: Q8FVU9). SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity)(Swiss-Prot: Q8FVU9). SIMILARITY: Belongs to the gcvP family(Swiss-Prot: Q8FVU9). MUTATION: gcvP encodes for glycine dehydrogenase and is required for persistent infection in mouse model [Ref6482:Ficht, 2003]. YH gcvP glycine dehydrogenase