bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella suis 1330 hfq protein RNA-binding protein Hfq UniProtKB: PR:P0A3G8 Gene name: hfq Molecule Role Annotation: FUNCTION: RNA-binding protein that stimulates the elongation of poly(A) tails (By similarity)(Swiss-Prot: P0A3G8). SIMILARITY: Belongs to the hfq family(Swiss-Prot: P0A3G8). MUTATION: hfq encodes for the RNA binding protein host factor I (HF-I). The hfq knock out strain has been showed a reduced growth rate and is unable to utilize glucose as a sole carbon source[Ref6495:Sonnleitner et al., 2003]. hfq is required for the efficient translation of the stationary-phase sigma factor RpoS in many bacteria, and a Brucella abortus hfq mutant displays a phenotype in vitro, which suggests that it has a generalized defect in stationary-phase physiology. The inability of the B. abortus hfq mutant to survive and replicate in a wild-type manner in cultured murine macrophages, and the profound attenuation displayed by this strain and its B melitensis counterpart in experimentally infected animals indicate that stationary -phase physiology plays an essential role in the capacity of the brucellae to establish and maintain long-term intracellular residence in host macrophages [Ref6495:Sonnleitner et al., 2003]. In contrast to B abortus 2308, the isogenic hfq and bacA mutants remained in acidic, LAMP-1 phagosomes and failed to initiate intracellular replication [Ref6495:Sonnleitner et al., 2003]. A hfq mutant of B abortus was eliminated from mouse spleens more rapidly than the wild type [Ref6495:Sonnleitner et al., 2003]. NCBIProteinAccess:NP_698116.1 PMID: 14521880 LocusTag: BR1111 NCBIProteinGI: 23501989 This protein is a Brucella virulence factor. FUNCTION: RNA-binding protein that stimulates the elongation of poly(A) tails (By similarity)(Swiss-Prot: P0A3G8). SIMILARITY: Belongs to the hfq family(Swiss-Prot: P0A3G8). MUTATION: hfq encodes for the RNA binding protein host factor I (HF-I). The hfq knock out strain has been showed a reduced growth rate and is unable to utilize glucose as a sole carbon source[Ref6495:Sonnleitner et al., 2003]. hfq is required for the efficient translation of the stationary-phase sigma factor RpoS in many bacteria, and a Brucella abortus hfq mutant displays a phenotype in vitro, which suggests that it has a generalized defect in stationary-phase physiology. The inability of the B. abortus hfq mutant to survive and replicate in a wild-type manner in cultured murine macrophages, and the profound attenuation displayed by this strain and its B melitensis counterpart in experimentally infected animals indicate that stationary -phase physiology plays an essential role in the capacity of the brucellae to establish and maintain long-term intracellular residence in host macrophages [Ref6495:Sonnleitner et al., 2003]. In contrast to B abortus 2308, the isogenic hfq and bacA mutants remained in acidic, LAMP-1 phagosomes and failed to initiate intracellular replication [Ref6495:Sonnleitner et al., 2003]. A hfq mutant of B abortus was eliminated from mouse spleens more rapidly than the wild type [Ref6495:Sonnleitner et al., 2003]. NCBIGene: 1166787