bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella suis 1330 omp19 protein lipoprotein Omp19 Molecule Role Annotation: SUBCELLULAR LOCATION: Outer membrane NCBIProteinGI: 23502780 NCBIGene: 1167630 This protein is a Brucella virulence factor. SUBCELLULAR LOCATION: Outer membrane LocusTag: BR1930 UniProtKB: PR:P0A3P2 NCBIProteinAccess:NP_698907.1 Gene name: omp19 PMID: lipid-anchor(Swiss-Prot: P0A3P2). MISCELLANEOUS: Elicits an immune response in humans, mice, sheep and goats infected with B.melitensis or B.abortus, but not in B.abortus-infected cattle(Swiss-Prot: P0A3P2). SIMILARITY: Belongs to the rhizobiaceae omp19 lipoprotein family(Swiss-Prot: P0A3P2). MUTATION: Omp19 is an immunoreactive outer membrane lipoprotein. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B abortus [Ref6473:Tibor et al., 2002].