bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella melitensis biovar Abortus 2308 gcvP protein glycine dehydrogenase This protein is a Brucella virulence factor. FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Gene name: gcvP PMID: CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity)(Swiss-Prot: Q8FVU9). CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2)(Swiss-Prot: Q8FVU9). COFACTOR: Pyridoxal phosphate (By similarity)(Swiss-Prot: Q8FVU9). SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity)(Swiss-Prot: Q8FVU9). SIMILARITY: Belongs to the gcvP family(Swiss-Prot: Q8FVU9). MUTATION: gcvP encodes for glycine dehydrogenase and is required for persistent infection in mouse model [Ref6482:Ficht, 2003]. NCBIProteinAccess:YP_418705.1 Molecule Role Annotation: FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor NCBIGene: 3828233 UniProtKB: PR:Q2YKX9 NCBIProteinGI: 83269414 LocusTag: BAB2_0515