bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella melitensis biovar Abortus 2308 ntrC protein CbxX/CfqX superfamily:Response regulator receiver:Sigma-54 factor interaction domain:Helix-turn-helix, Fis-type:AAA ATPase Gene name: ntrC Molecule Role Annotation: MUTATION: ntrC encodes for a response regulator subfamily (NtrC). A B suis ntrC isogenic mutant was constructed which showed no significant differences in growth rates compared to the wild-type strain when grown at different temperatures in vitro. However, the mutant exhibited a reduction in metabolic activity in the presence of many amino acids. The mutation did not affect survival or multiplication of B suis in macrophages, but during the initial stages of infection in the murine brucellosis model, the ntrC mutant showed a reduced ability to multiply rapidly in splenic tissue [Ref6496:Dorrell et al., 1999]. This protein is a Brucella virulence factor. MUTATION: ntrC encodes for a response regulator subfamily (NtrC). A B suis ntrC isogenic mutant was constructed which showed no significant differences in growth rates compared to the wild-type strain when grown at different temperatures in vitro. However, the mutant exhibited a reduction in metabolic activity in the presence of many amino acids. The mutation did not affect survival or multiplication of B suis in macrophages, but during the initial stages of infection in the murine brucellosis model, the ntrC mutant showed a reduced ability to multiply rapidly in splenic tissue [Ref6496:Dorrell et al., 1999]. NCBIProteinGI: 82699958 NCBIProteinAccess:YP_414532.1 UniProtKB: PR:Q2YPW4 NCBIGene: 3788817 LocusTag: BAB1_1140 PMID: 10373105