bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella suis 1330 fliF protein flagellar MS-ring protein NCBIGene: 1165599 This protein is a Brucella virulence factor. FUNCTION: The M ring may be actively involved in energy transduction (By similarity)(Swiss-Prot: Q8FUS3). SUBUNIT: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity)(Swiss-Prot: Q8FUS3). SUBCELLULAR LOCATION: Inner membrane Gene name: fliF LocusTag: BRA1146 Molecule Role Annotation: FUNCTION: The M ring may be actively involved in energy transduction (By similarity)(Swiss-Prot: Q8FUS3). SUBUNIT: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity)(Swiss-Prot: Q8FUS3). SUBCELLULAR LOCATION: Inner membrane NCBIProteinGI: 23500860 NCBIProteinAccess:NP_700300.1 UniProtKB: PR:Q8FUS3 PMID: multi-pass membrane protein (By similarity)(Swiss-Prot: Q8FUS3). SIMILARITY: Belongs to the fliF family(Swiss-Prot: Q8FUS3). MUTATION: fliF is a gene potentially coding for the MS ring, a basal component of the flagellar system. Its mutant through signature- tagged mutagenesis is attenuated in vivo. It implicate a role for flagella in virulenc [Ref6480:Lestrate et al., 2003].