bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella suis 1330 bacA protein transport protein PMID: 10741969 NCBIProteinGI: 23501276 NCBIProteinAccess:NP_697403.1 NCBIGene: 1166033 Gene name: bacA LocusTag: BR0372 Molecule Role Annotation: MUTATION: B abortus bacA mutant exhibited decreased survival in macrophages and greatly accelerated clearance from experimentally infected mice compared to the virulent parental strain [Ref6487:LeVier et al., 2000]. R meliloti bacA gene encodes a putative cytoplasmic membrane transport protein required for symbiosis [Ref6487:LeVier et al., 2000]. The BacA protein is essential for the long-term survival of Sinorhizobium meliloti and Brucella abortus within acidic compartments in plant and animal cells , respectively. Mutation study showed that B. abortus BacA affects the distribution of LPS fatty acids, including a very-long-chain fatty acid thought to be unique to the alpha-proteobacteria[Ref6487:LeVier et al., 2000]. This protein is a Brucella virulence factor. MUTATION: B abortus bacA mutant exhibited decreased survival in macrophages and greatly accelerated clearance from experimentally infected mice compared to the virulent parental strain [Ref6487:LeVier et al., 2000]. R meliloti bacA gene encodes a putative cytoplasmic membrane transport protein required for symbiosis [Ref6487:LeVier et al., 2000]. The BacA protein is essential for the long-term survival of Sinorhizobium meliloti and Brucella abortus within acidic compartments in plant and animal cells , respectively. Mutation study showed that B. abortus BacA affects the distribution of LPS fatty acids, including a very-long-chain fatty acid thought to be unique to the alpha-proteobacteria[Ref6487:LeVier et al., 2000]. UniProtKB: PR:Q8G2F1