bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella suis 1330 BR0144 protein PII uridylyl-transferase Molecule Role Annotation: FUNCTION: Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein (By similarity)(Swiss-Prot: Q8G312). CATALYTIC ACTIVITY: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII](Swiss-Prot: Q8G312). SIMILARITY: Belongs to the glnD family(Swiss-Prot: Q8G312). MUTATION: glnD encodes for a uridylyl transferase which is the primary sensor of nitrogen. The glnD mutant via signature-tagged transposon mutagenesis is attenuated in THP1 macrophages and HeLa cells. It supports the hypothesis that the concentration of glutamine in host cells is critical for the intracellular survival of Brucella [Ref6484:Foulongne et al., 2000]. NCBIGene: 1165801 This protein is a Brucella virulence factor. FUNCTION: Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein (By similarity)(Swiss-Prot: Q8G312). CATALYTIC ACTIVITY: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII](Swiss-Prot: Q8G312). SIMILARITY: Belongs to the glnD family(Swiss-Prot: Q8G312). MUTATION: glnD encodes for a uridylyl transferase which is the primary sensor of nitrogen. The glnD mutant via signature-tagged transposon mutagenesis is attenuated in THP1 macrophages and HeLa cells. It supports the hypothesis that the concentration of glutamine in host cells is critical for the intracellular survival of Brucella [Ref6484:Foulongne et al., 2000]. NCBIProteinGI: 23501056 UniProtKB: PR:Q8G312 Gene name: glnD PMID: 10678941 LocusTag: BR0144 NCBIProteinAccess:NP_697183.1