bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella suis 1330 pheA protein prephenate dehydratase Gene name: pheA NCBIProteinAccess:NP_697079.1 This protein is a Brucella virulence factor. MUTATION: The product of pheA gene is specifically dedicated to the biosynthesis of phenylalanine. The B. abortus pheA mutant with mini-Tn5 disruption displays nutritional defects in vitro. Experimental findings with the B abortus ilvD, trpB, and pheA mutants suggest that tryptophan and phenylalanine are available to the brucellae in their intracellular niche but that other amino acids (eg, leucine, isoleucine, or valine) are not. The pheA::miniTn5 mutant displayed attenuation in macrophages but not in mice [Ref6485:Alcantara et al., 2004]. Molecule Role Annotation: MUTATION: The product of pheA gene is specifically dedicated to the biosynthesis of phenylalanine. The B. abortus pheA mutant with mini-Tn5 disruption displays nutritional defects in vitro. Experimental findings with the B abortus ilvD, trpB, and pheA mutants suggest that tryptophan and phenylalanine are available to the brucellae in their intracellular niche but that other amino acids (eg, leucine, isoleucine, or valine) are not. The pheA::miniTn5 mutant displayed attenuation in macrophages but not in mice [Ref6485:Alcantara et al., 2004]. NCBIGene: 1165694 UniProtKB: PR:Q8G3B3 PMID: 15271960 LocusTag: BR0037 NCBIProteinGI: 23500952