bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella melitensis bv. 1 str. 16M BMEI2041 protein imidazole glycerol phosphate synthase subunit HisF LocusTag: BMEI2041 Gene name: hisF NCBIGene: 1197752 UniProtKB: PR:Q8YE37 NCBIProteinGI: 17988324 Molecule Role Annotation: FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit (By similarity)(Swiss-Prot: Q8FY07). CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O(Swiss-Prot: Q8FY07). PATHWAY: Amino-acid biosynthesis NCBIProteinAccess:NP_540958.1 PMID: L-histidine biosynthesis This protein is a Brucella virulence factor. FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit (By similarity)(Swiss-Prot: Q8FY07). CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O(Swiss-Prot: Q8FY07). PATHWAY: Amino-acid biosynthesis