bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella melitensis bv. 1 str. 16M BMEI1886 protein phosphoglucomutase LocusTag: BMEI1886 NCBIProteinAccess:NP_540803.1 Molecule Role Annotation: MUTATION: Brucella pgm encodes the phosphoglucomutase. The B. abortus pgm mutant (B2211) lacks the O antigen. However, the core region of the mutant LPS migrated in Tricine-PAGE electrophoresis in a position that was indistinguishable from that of the wild type core. Although the exponential intracellular replication of the pgm mutant was delayed by approximately 20 h with respect to that of the wild type, the high number of recoverable bacteria at 48 h postinfection indicates that mutant strain B2211 replicates inside HeLa host cells [Ref6486:Ugalde et al., 2000]. B abortus phosphoglucomutase (pgm) insertional mutants were attenuated in vivo but not in vitro [Ref6534:Ko and Splitter, 2003]. Gene name: pgm This protein is a Brucella virulence factor. MUTATION: Brucella pgm encodes the phosphoglucomutase. The B. abortus pgm mutant (B2211) lacks the O antigen. However, the core region of the mutant LPS migrated in Tricine-PAGE electrophoresis in a position that was indistinguishable from that of the wild type core. Although the exponential intracellular replication of the pgm mutant was delayed by approximately 20 h with respect to that of the wild type, the high number of recoverable bacteria at 48 h postinfection indicates that mutant strain B2211 replicates inside HeLa host cells [Ref6486:Ugalde et al., 2000]. B abortus phosphoglucomutase (pgm) insertional mutants were attenuated in vivo but not in vitro [Ref6534:Ko and Splitter, 2003]. NCBIGene: 1197597 NCBIProteinGI: 17988169 UniProtKB: PR:Q8YEJ2 PMID: 10992476, 12525425