bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella melitensis bv. 1 str. 16M BMEI1804 protein PII uridylyl-transferase LocusTag: BMEI1804 This protein is a Brucella virulence factor. FUNCTION: Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein (By similarity)(Swiss-Prot: Q8G312). CATALYTIC ACTIVITY: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII](Swiss-Prot: Q8G312). SIMILARITY: Belongs to the glnD family(Swiss-Prot: Q8G312). MUTATION: glnD encodes for a uridylyl transferase which is the primary sensor of nitrogen. The glnD mutant via signature-tagged transposon mutagenesis is attenuated in THP1 macrophages and HeLa cells. It supports the hypothesis that the concentration of glutamine in host cells is critical for the intracellular survival of Brucella [Ref6484:Foulongne et al., 2000]. Gene name: glnD Molecule Role Annotation: FUNCTION: Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein (By similarity)(Swiss-Prot: Q8G312). CATALYTIC ACTIVITY: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII](Swiss-Prot: Q8G312). SIMILARITY: Belongs to the glnD family(Swiss-Prot: Q8G312). MUTATION: glnD encodes for a uridylyl transferase which is the primary sensor of nitrogen. The glnD mutant via signature-tagged transposon mutagenesis is attenuated in THP1 macrophages and HeLa cells. It supports the hypothesis that the concentration of glutamine in host cells is critical for the intracellular survival of Brucella [Ref6484:Foulongne et al., 2000]. NCBIProteinAccess:NP_540721.1 NCBIGene: 1197515 UniProtKB: PR:Q8YES3 NCBIProteinGI: 17988087 PMID: 10678941