bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella melitensis bv. 1 str. 16M uvrA protein excinuclease ABC subunit A LocusTag: BMEI0878 NCBIProteinAccess:NP_539795.1 Molecule Role Annotation: FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate (By similarity)(Swiss-Prot: Q8G0I9). SUBUNIT: Forms a heterotetramer with uvrB during the search for lesions (By similarity)(Swiss-Prot: Q8G0I9). SUBCELLULAR LOCATION: Cytoplasm (By similarity)(Swiss-Prot: Q8G0I9). SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily(Swiss-Prot: Q8G0I9). SIMILARITY: Contains 2 ABC transporter domains(Swiss-Prot: Q8G0I9). MUTATION: B. abortus urvA and recA mutants exhibited greater sensitivity than the wild-type strain. Mutant strains carrying inactivated uvrA genes are typically less sensitive than recA mutants because there is only the loss of the nucleotide excision repair system, just one subset of the larger repair networks. However, it was found that the recA mutant conferred only a modest sensitivity to UV, substantially less sensitive than the uvrA mutant. High basal recA expression was observed in the uvrA repair mutant. The B abortus recA mutant exhibited a nearly fourfold decline in survival to murine peritoneal macrophages but nominal sensitivity for the uvrA and radA repair mutants [Ref6493:Roux et al., 2006]. This protein is a Brucella virulence factor. FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate (By similarity)(Swiss-Prot: Q8G0I9). SUBUNIT: Forms a heterotetramer with uvrB during the search for lesions (By similarity)(Swiss-Prot: Q8G0I9). SUBCELLULAR LOCATION: Cytoplasm (By similarity)(Swiss-Prot: Q8G0I9). SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily(Swiss-Prot: Q8G0I9). SIMILARITY: Contains 2 ABC transporter domains(Swiss-Prot: Q8G0I9). MUTATION: B. abortus urvA and recA mutants exhibited greater sensitivity than the wild-type strain. Mutant strains carrying inactivated uvrA genes are typically less sensitive than recA mutants because there is only the loss of the nucleotide excision repair system, just one subset of the larger repair networks. However, it was found that the recA mutant conferred only a modest sensitivity to UV, substantially less sensitive than the uvrA mutant. High basal recA expression was observed in the uvrA repair mutant. The B abortus recA mutant exhibited a nearly fourfold decline in survival to murine peritoneal macrophages but nominal sensitivity for the uvrA and radA repair mutants [Ref6493:Roux et al., 2006]. PMID: 16816190 NCBIProteinGI: 17987161 Gene name: uvrA UniProtKB: PR:Q8YHC4 NCBIGene: 1196589