bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella melitensis bv. 1 str. 16M BMEI0827 protein UNDECAPRENYL PYROPHOSPHATE SYNTHETASE NCBIProteinGI: 17987110 Molecule Role Annotation: FUNCTION: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide (By similarity)(Swiss-Prot: Q8G0D9). CATALYTIC ACTIVITY: Di-trans,poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans,poly-cis-undecaprenyl diphosphate(Swiss-Prot: Q8G0D9). COFACTOR: Magnesium (By similarity)(Swiss-Prot: Q8G0D9). SUBUNIT: Homodimer (By similarity)(Swiss-Prot: Q8G0D9). SIMILARITY: Belongs to the UPP synthetase family(Swiss-Prot: Q8G0D9). MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis uppS gene is required for intracellular multiplication in human macrophage THP-1 cells [Ref412:Kohler et al., 2002]. NCBIGene: 1196538 This protein is a Brucella virulence factor. FUNCTION: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide (By similarity)(Swiss-Prot: Q8G0D9). CATALYTIC ACTIVITY: Di-trans,poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans,poly-cis-undecaprenyl diphosphate(Swiss-Prot: Q8G0D9). COFACTOR: Magnesium (By similarity)(Swiss-Prot: Q8G0D9). SUBUNIT: Homodimer (By similarity)(Swiss-Prot: Q8G0D9). SIMILARITY: Belongs to the UPP synthetase family(Swiss-Prot: Q8G0D9). MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis uppS gene is required for intracellular multiplication in human macrophage THP-1 cells [Ref412:Kohler et al., 2002]. LocusTag: BMEI0827 UniProtKB: PR:Q8YHH3 Gene name: uppS PMID: 12438693 NCBIProteinAccess:NP_539744.1