bearer of at some time only_in_taxon Brucella virulence factor disposition Brucella melitensis bv. 1 str. 16M BMEI0157 protein isopropylmalate isomerase large subunit Gene name: leuC NCBIProteinAccess:NP_539075.1 NCBIGene: 1195869 UniProtKB: PR:Q8YJC9 This protein is a Brucella virulence factor. FUNCTION: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate(Swiss-Prot: Q8FYG9). CATALYTIC ACTIVITY: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmaleate + H(2)O(Swiss-Prot: Q8FYG9). CATALYTIC ACTIVITY: (2S)-2-isopropylmaleate + H(2)O = 3-hydroxy-4-methyl-3-carboxypentanoate(Swiss-Prot: Q8FYG9). COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity)(Swiss-Prot: Q8FYG9). PATHWAY: Amino-acid biosynthesis LocusTag: BMEI0157 Molecule Role Annotation: FUNCTION: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate(Swiss-Prot: Q8FYG9). CATALYTIC ACTIVITY: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmaleate + H(2)O(Swiss-Prot: Q8FYG9). CATALYTIC ACTIVITY: (2S)-2-isopropylmaleate + H(2)O = 3-hydroxy-4-methyl-3-carboxypentanoate(Swiss-Prot: Q8FYG9). COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity)(Swiss-Prot: Q8FYG9). PATHWAY: Amino-acid biosynthesis NCBIProteinGI: 17986441 PMID: L-leucine biosynthesis