has_part has part has_part Brucella abortus lipopolysaccharide Brucella O-polysaccharide Brucella abortus vaccine RB51 Brucella abortus vaccine RB51 is a Brucella abortus vaccine that is licensed in the USA since 1992. Strain RB51 has a rough colonial morphology and lacks the O polysaccharide of LPS. (Schurig, G. G., R. M. Roop II, T. Bagchi, S. Boyle, D. Buhrman, and N. Sriranganathan. 1991. Biological properties of RB51: a stable rough strain of Brucella abortus. Vet. Microbiol. 28:171–188.) SRB51 Brucella RB-51 Brucella RB51 B. abortus RB51 RB51 has an insertion within wboA gene that leads to the lack of Brucella LPS O-antigen and the rough phenotype.The wboA gene encoding a glycosyltransferase, an enzyme essential for the synthesis of O antigen, is disrupted by an IS711 element in B. abortus vaccine strain RB51. [Identification of an IS711 element interrupting the wboA gene of Brucella abortus vaccine strain RB51 and a PCR assay to distinguish strain RB51 from other Brucella species and strains. Vemulapalli R, McQuiston JR, Schurig GG, Sriranganathan N, Halling SM, Boyle SM. Clin Diagn Lab Immunol. 1999 Sep;6(5):760-4. PMID: 10473532] live attenuated Brucella abortus vaccine