has_part
has part
has_part
has disposition at some time
attenuated disposition
B. abortus uvrA mutant
B. abortus 2308 uvrA mutant
The gene uvrA from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene.
PMID: 16816190
A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene uvrA.
UniProtKB accession: Q2YPX5
Information about the mutated molecule: FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate (By similarity)(Swiss-Prot: Q8G0I9). SUBUNIT: Forms a heterotetramer with uvrB during the search for lesions (By similarity)(Swiss-Prot: Q8G0I9). SUBCELLULAR LOCATION: Cytoplasm (By similarity)(Swiss-Prot: Q8G0I9). SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily(Swiss-Prot: Q8G0I9). SIMILARITY: Contains 2 ABC transporter domains(Swiss-Prot: Q8G0I9). MUTATION: B. abortus urvA and recA mutants exhibited greater sensitivity than the wild-type strain. Mutant strains carrying inactivated uvrA genes are typically less sensitive than recA mutants because there is only the loss of the nucleotide excision repair system, just one subset of the larger repair networks. However, it was found that the recA mutant conferred only a modest sensitivity to UV, substantially less sensitive than the uvrA mutant. High basal recA expression was observed in the uvrA repair mutant. The B abortus recA mutant exhibited a nearly fourfold decline in survival to murine peritoneal macrophages but nominal sensitivity for the uvrA and radA repair mutants [Ref6493:Roux et al., 2006].
YH
NCBIGene: 3787776
uvrA
excinuclease ABC subunit A