has_part
has part
has_part
has disposition at some time
attenuated disposition
B. abortus pheA mutant
B. abortus 2308 pheA mutant
YH
NCBIGene: 3788850
A mutant of strain Brucella melitensis biovar Abortus 2308 that lacks an intact gene pheA.
UniProtKB accession: Q2YPM5
Information about the mutated molecule: MUTATION: The product of pheA gene is specifically dedicated to the biosynthesis of phenylalanine. The B. abortus pheA mutant with mini-Tn5 disruption displays nutritional defects in vitro. Experimental findings with the B abortus ilvD, trpB, and pheA mutants suggest that tryptophan and phenylalanine are available to the brucellae in their intracellular niche but that other amino acids (eg, leucine, isoleucine, or valine) are not. The pheA::miniTn5 mutant displayed attenuation in macrophages but not in mice [Ref6485:Alcantara et al., 2004].
PMID: 15271960
The gene pheA from the strain Brucella melitensis biovar Abortus 2308 is a virulence gene.
pheA
prephenate dehydratase