part of Cell differentiation JAK STAT pathway GO:0007259 IEV:0000044 IEV:0000137 KEGG:hsa04630 The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. event Cell proliferation Cell cycle Immune response Tumorigenesis Hematopoiesis Signaling pathway