part of Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA) GDP-GTP exchange of G alpha in cytosol GDP-GTP exchange of G alpha s in cytosol IEV:0000722 IMR:0000317 IMR:0001354 IMR:0001357 PubMed:14734786 event G alpha s GDP-GTP exchange signaling Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through G alpha s GDP-GTP exchange signaling)