part of Binding in inner space of nucleus Binding of p27 and Cdk2 in inner space of nucleus IEV:0001090 IMR:0100384 IMR:0100598 Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import. REACT:334.3 event Negative regulation of S phase TGF beta super family signaling (through p27) Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)