Binding in inner space of nucleus Binding of 14-3-3 and HDAC5/7 in cytosol and/or nucleus Binding of 14-3-3 and HDAC5 in inner space of nucleus CaMK-mediated nuclear export of HDAC5 appears to require binding of 14-3-3 to Ser-259 and Ser-498 in its amino terminus. Indeed, substitution of these serines with alanines blocks both 14-3-3 binding and nuclear export of HDAC5. However, association with 14-3-3 alone is not sufficient to localize HDAC5 in the cytoplasm, since NES mutants of HDAC5 associate with 14-3-3 in a CaMK-dependent manner but remain in the nucleus. IEV:0001731 IMR:0000456 IMR:0001171 PubMed:11509672 PubMed:15923258 event