adaptor protein SH2/SH3 adaptor protein GO:0005070 IMR:0000334 This term refers to the adaptor proteins that possesses both SH2 and SH3 domains, such as Grb2, Nck and Crk, and does not include adaptor proteins that contain only SH2 or PTB domains, such as the Shc family and the IRS family. molecule_role