transcriptional regulator PEBP2/CBF IMR:0000412 The PEBP2/CBF is a heterodimer consists of DNA binding alpha subunits and a beta subunit (CBFbeta) that does not bind DNA directly but that enhances the binding of the alpha subunit. Multiple alpha subunit genes, including CBFA1, AML1 (CBFA2), and CBFA3, have been detected. All of the CBFalpha proteins contain a runt domain, which is similar to the Drosophila pair-rule gene, runt. molecule_role polyomavirus enhancer binding protein 2/core-binding factor