phosphatidylinositol polyphosphate PI(3,4,5)P3 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate IMR:0001352 IMR:0200396 KEGG:C05981 PI(3,4,5)P2 is generated by phosphorylation of PI(4,5)P at the 3 position of the inositol ring catalyzed by PI3-kinase. NOT cleaved by phospholipase C. PIP3 Phosphatidylinositol-3,4,5-trisphosphate molecule_role