negatively regulates regulation of transcription by binding to promoter negative regulation of transcription by binding to promoter negatively regulate // promoter, negatively regulated // promoter, repressed // promoter, represses // promoter, repress // promoter, binds // transcriptional start site // repressor, bound // transcriptional start site // repressor Transcription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. Depending on the transcription factor, the transcription of the adjacent gene is either up- or down-regulated. (Ref: https://en.wikipedia.org/wiki/Transcription_factor). "We show that GerE binds to two sites that span the -35 region of the cotD promoter." (Reference: http://www.ncbi.nlm.nih.gov/pubmed/10075739) a regulation of transcription by binding to promoter that is further classified as a positive regulation YH, AO gene transcription