has characteristic is similar to uses multi-state agent-based simulation method StochSim nearest-neighbour algorithm http://identifiers.org/pubmed/11395441 Stochsim 1.2 and more recent versions The nearest-neighbour algorithm allows for the representation of spatial information, by adding a two-dimensional lattice in the form of a probabilistic cellular automata. That way, nearest neighbour interactions do additionally influence reactions taking place in the systems. Reactions between entities are calculated using the agent-based simulation algorithm [http://identifiers.org/biomodels.kisao/KISAO_0000017]. spatial description stochastic system behaviour cellular automata update method rule-based simulation method