uses Elf and Ehrenberg method http://identifiers.org/doi/10.1049/sb:20045021 Elf algorithm MesoRD NSM SmartCell Sub-volume stochastic reaction-diffusion method that is a combination of the Direct Method [http://identifiers.org/biomodels.kisao/KISAO_0000029] for sampling the time for a next reaction or diffusion event in each subvolume, with Gibson and Bruck's Next Reaction Method [http://identifiers.org/biomodels.kisao/KISAO_0000027], which is used to keep track of in which subvolume an event occurs next. The subvolumes are kept sorted in a queue, implemented as a binary tree, according to increasing time of the next event. When an event has occurred in the subvolume at the top of the queue, new event times need to be sampled only for one (the event is a chemical reaction) or two (the event is a diffusion jump) subvolume(s). next-subvolume method Gibson-Bruck next reaction algorithm Gillespie direct algorithm Stundzia and Lumsden method sub-volume stochastic reaction-diffusion algorithm