has parameter is similar to tau-leaping method binomial tau-leaping method 1 2007-10-16 http://identifiers.org/doi/10.1063/1.2771548 BtauL Coarse grained modified version of the next subvolume method [http://identifiers.org/biomodels.kisao/KISAO_0000022] that allows the user to consider both diffusion and reaction events in relatively long simulation time spans as compared with the original method and other commonly used fully stochastic computational methods. binomial tau-leap spatial stochastic simulation algorithm dk sub-volume stochastic reaction-diffusion algorithm coarse-graining factor