has characteristic has parameter Runge-Kutta based method deterministic system behaviour progression with fixed time step implicit method type Radau method 2011-05-11 http://identifiers.org/biosimulators/jsim urn:issn:1088-6842(e) AZ Implicit Runge-Kutta methods based on Radau quadrature. implicit Runge-Kutta method based on Radau quadrature ordinary differential equation problem maximum order minimum order initial order