E-Cell multi-algorithm simulation method 2011-05-23 http://identifiers.org/biosimulators/ecell4 http://identifiers.org/pubmed/14990450 A modular meta-algorithm with a discrete event scheduler that can incorporate any type of time-driven simulation algorithm. It was shown that this meta-algorithm can efficiently drive simulation models with different simulation algorithms with little intrusive modification to the algorithms themselves. Only a few additional methods to handle communications between computational modules are required. AZ hybrid method