has characteristic is similar to exact solution R-leaping algorithm exact R-leaping algorithm 2011-06-03 http://identifiers.org/pubmed/2852436 AZ ER-leap method We present a SSA which, similar to R-leap [http://identifiers.org/biomodels.kisao/KISAO_0000330], accelerates SSA [http://identifiers.org/biomodels.kisao/KISAO_0000029] by executing multiple reactions per algorithmic step, but which samples the reactant trajectories from the same probability distribution as the SSA. This 'exact R-leap' or 'ER-leap' algorithm is a modification of the R-leap algorithm which is both exact and capable of substantial speed-up over SSA. exact R-leap method exact accelerated stochastic simulation algorithm stochastic simulation leaping method