is generalization of tau-leaping method binomial tau-leaping method multinomial tau-leaping method 2011-06-09 http://identifiers.org/pubmed/17343434 AZ MtauL The multinomial tau-leaping method is an extension of the binomial tau-leaping method [http://identifiers.org/biomodels.kisao/KISAO_0000074] to networks with arbitrary multiple-channel reactant dependencies. Improvements were achieved by a combination of three factors: First, tau-leaping steps are determined simply and efficiently using a-priori information and Poisson distribution based estimates of expectation values for reaction numbers. Second, networks are partitioned into closed groups of reactions and corresponding reactants in which no group reactant set is found in any other group. Third, product formation is factored into upper bound estimation of the number of times a particular reaction occurs.