has characteristic modelling and simulation algorithm deterministic system behaviour metamodelling method 2012-01-18 http://identifiers.org/doi/10.1186/1752-0509-5-90 true AZ Deterministic dynamic models of complex biological systems contain a large number of parameters and state variables, related through nonlinear differential equations with various types of feedback. A metamodel of such a dynamic model is a statistical approximation model that maps variation in parameters and initial conditions (inputs) to variation in features of the trajectories of the state variables (outputs) throughout the entire biologically relevant input space.