has characteristic is hybrid of has parameter uses modelling and simulation algorithm Gillespie first reaction algorithm tau-leaping method deterministic system behaviour absolute tolerance hybrid method COAST 1 2013-01-28 http://identifiers.org/pubmed/17100426 AZ An approximative algorithm for stochastic simulations of chemical reaction systems based on three different modeling levels: for small numbers of particles an exact [http://identifiers.org/biomodels.kisao/KISAO_0000236] stochastic [http://identifiers.org/biomodels.kisao/KISAO_0000104] model; for intermediate numbers an approximative [http://identifiers.org/biomodels.kisao/KISAO_0000237], but computationally more efficient stochastic [http://identifiers.org/biomodels.kisao/KISAO_0000104] model based on discrete Gaussian distributions; and for large numbers the deterministic [http://identifiers.org/biomodels.kisao/KISAO_0000103] reaction kinetics. In every simulation time step, the subdivision of the reaction channels into the three different modeling levels is done automatically, where all approximations applied can be controlled by a single error parameter for which an appropriate value can easily be found. Requested by Mark Moeller on Friday, January 25, 2013 11:11:30 AM. controllable approximative stochastic reaction algorithm