has parameter is similar to uses CVODE CVODE-like method CVODES 1 1 1 1 1 http://computation.llnl.gov/projects/sundials/cvodes http://identifiers.org/biosimulators/amici CVODES is a solver for stiff and nonstiff ODE systems (initial value problem) given in explicit form y’ = f(t,y,p) with sensitivity analysis capabilities (both forward and adjoint modes). CVODES is a superset of CVODE [http://identifiers.org/biomodels.kisao/KISAO_0000019] and hence all options available to CVODE (with the exception of the FCVODE interface module) are also available for CVODES. Both integration methods (Adams-Moulton [http://identifiers.org/biomodels.kisao/KISAO_0000280] and BDF [http://identifiers.org/biomodels.kisao/KISAO_0000288]) and the corresponding nonlinear iteration methods, as well as all linear solver and preconditioner modules, are available for the integration of the original ODEs, the sensitivity systems, or the adjoint system. SUNDIALS KLU stability limit detection flag absolute quadrature tolerance relative quadrature tolerance absolute steady-state tolerance relative steady-state tolerance