is hybrid of Gibson-Bruck next reaction algorithm LSODA Pahle hybrid method Pahle hybrid Gibson-Bruck Next Reaction method/LSODA method 2020-10-29 http://identifiers.org/biosimulators/copasi http://identifiers.org/doi/10.1007/978-1-59745-525-1_2 http://identifiers.org/doi/10.1016/j.jbiotec.2017.06.1200 http://identifiers.org/doi/10.1093/bioinformatics/btl485 http://identifiers.org/doi/10.5555/1218112.1218421 Combines a deterministic numerical integration of ODEs with a stochastic simulation algorithm. The whole biochemical network is partitioned into a deterministic and a stochastic subnet internally. The deterministic subnet contains all reactions in which only species with high particle numbers take part. All reactions with at least one low-numbered species are in the stochastic subnet. The partitioning of the biochemical network can change dynamically during the simulation. The reaction probabilities of the stochastic subnet are approximated as constant during one stochastic step. The deterministic subnet is integrated with LSODA. The stochastic subnet is simulated by the Gibson-Bruck Next Reaction Method. JRK