has parameter quadratic MOMA 2020-10-29 http://identifiers.org/biosimulators/cobratoolbox http://identifiers.org/biosimulators/optflux http://identifiers.org/biosimulators/raven http://identifiers.org/doi/10.1073/pnas.232349399 JRK MOMA Minimization of metabolic adjustment (MOMA) is an extension of FBA for the prediction of flux distributions in gene knockouts. MOMA employs quadratic programming to identify the closest point (in terms of its Euclidean distance) in the permissible flux space of the knockout to the wild-type flux vector by solving the optimization problem Min sum((fluxAi - fluxBi)^2) + sum(fluxAi)^(fluxMinimizationWeight) + sum(fluxBi)^(fluxMinimizationWeight) Quadratic Minimization of Metabolic Adjustment minimization of metabolic adjustment quadratic minimization of metabolic adjustment flux minimization weight linear MOMA MOMA