is hybrid of Gibson-Bruck next reaction algorithm Milstein method hybrid method hybrid adaptive Gibson - Milstein method 2021-01-13 http://identifiers.org/biosimulators/vcell http://identifiers.org/doi/10.1186/1471-2105-7-93 A hybrid stochastic method partitions the system into subsets of fast and slow reactions and approximates the fast reactions as a continuous Markov process, using a chemical Langevin equation, and accurately describes the slow dynamics using the Gibson algorithm. Fixed time step Milstein is used for approximate numerical solution of CLE. JRK MLB