has characteristic
is hybrid of
has parameter
Gibson-Bruck next reaction algorithm
deterministic system behaviour
stochastic system behaviour
particle number lower limit
particle number upper limit
Pahle hybrid method
1
1
http://identifiers.org/biosimulators/copasi
http://identifiers.org/doi/10.1093/bioinformatics/btl485
true
AZ
The hybrid method combines the stochastic 'Gibson-Bruck's next reaction method' [http://identifiers.org/biomodels.kisao/KISAO_0000027] with different algorithms for the numerical integration of ODEs [http://identifiers.org/biomodels.kisao/KISAO_0000245 some http://identifiers.org/biomodels.kisao/KISAO_0000374]. The biochemical network is dynamically partitioned into a deterministic and a stochastic subnet depending on the current particle numbers in the system. The user can define limits for when a particle number should be considered low or high. The stochastic subnet contains reactions involving low numbered species as substrate or product. All the other reactions form the deterministic subnet. The two subnets are then simulated in parallel using the stochastic and deterministic solver, respectively. The reaction probabilities in the stochastic subnet are approximated as constant between two stochastic reaction events.
hybrid method
ordinary differential equation problem