is parameter of
has type
nonnegative Poisson tau-leaping method
critical firing threshold
The 'nonnegative Poisson tau-leaping method' [http://identifiers.org/biomodels.kisao/KISAO_0000084] is based on the fact that negative populations typically arise from multiple firings of reactions that are only a few firings away from consuming all the molecules of one of their reactants. To focus on those reaction channels, the modified tau-leaping algorithm introduces a second control parameter nc, a positive integer that is usually set somewhere between 5 and 20. Any reaction channel with a positive propensity function that is currently within nc firings of exhausting one of its reactants is then classified as a critical reaction. The modified algorithm chooses tau in such a way that no more than one firing of all the critical reactions can occur during the leap.
nonnegative tau-leaping second control parameter
partitioning control parameter