part_of part of part of has_part has part has part has plasma membrane part develops_from develops from develops from capable of capable_of capable of osteoclast A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. FMA:66781 chondroclast MESH:D010010 CALOHA:TS-0721 BTO:0000968 Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. phagocyte (sensu Vertebrata) monocyte myeloid leukocyte bone cell bone resorption cathepsin K tartrate-resistant acid phosphatase type 5 transcription factor PU.1 tumor necrosis factor receptor superfamily member 11A macrophage colony-stimulating factor 1 receptor protein c-Fos nuclear factor NF-kappa-B p100 subunit protein-containing material entity bone element