has_part has part has part lacks_part bearer of bearer of bearer_of has characteristic is bearer of has plasma membrane part capable of capable_of capable of mature neutrophil mature neutrocyte mature neutrophilic leukocyte polymorphonuclear leukocyte polymorphonuclear leucocyte mature neutrophil leukocyte poly mature neutrophilic leucocyte mature neutrophil leucocyte BTO:0003473 polynuclear neutrophilic leukocyte polymorphonuclear neutrophil A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive. Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). PMN polynuclear neutrophilic leucocyte phagocyte neutrophil neutrophillic cytoplasm respiratory burst involved in inflammatory response positive regulation of leukocyte chemotaxis nucleus phagocytosis interleukin-8 production tertiary granule Homo sapiens Homo sapiens lobed C-X-C chemokine receptor type 1 C-X-C chemokine receptor type 2 alpha-(1,3)-fucosyltransferase 4 low affinity immunoglobulin gamma Fc region receptor III leukosialin transcription factor PU.1 protein c-Fos lactotransferrin myeloperoxidase myb proto-oncogene protein