has_part has part has part lacks_plasma_membrane_part cell has gene marker has plasma membrane part develops_from develops from develops from lacks_plasma_membrane_part plasma cell BTO:0000392 plasma B-cell plasmacyte effector B-cell plasma B cell MESH:D010950 plasmocyte FMA:70574 effector B cell cell Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. antibody secreting cell plasmablast cartwheel heterochromatin cartwheel heterochromatin Golgi apparatus immunoglobulin complex MHC class II protein complex Homo sapiens Homo sapiens CD38 IGJ IGKC MZB1 FCRL5 membrane-spanning 4-domains subfamily A member 1 syndecan-1