starts with starts with G protein-coupled receptor activity signal transduction G protein-coupled receptor signaling pathway G-protein-coupled receptor protein signalling pathway G-protein coupled receptor protein signal transduction G-protein coupled receptor signaling pathway via GPCR dimer GO:0038042 The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. GPCR signaling pathway biological_process dimeric G-protein coupled receptor signalling pathway G-protein coupled receptor signalling pathway dimeric G-protein coupled receptor signaling pathway G protein coupled receptor protein signaling pathway GPCR signalling pathway G protein coupled receptor protein signalling pathway G-protein coupled receptor protein signaling pathway GO:0007186