tumor necrosis factor production Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. tumor necrosis factor biosynthetic process sl TNF-alpha biosynthesis TNF-alpha biosynthetic process GO:0032640 TNF-alpha production TNF alpha biosynthesis Tnfa production tumor necrosis factor-alpha production tumor necrosis factor synthesis biological_process The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. TNF biosynthetic process 2015-06-15T22:59:26Z cachectin production TNF production TNF biosynthesis tumor necrosis factor secretion GO:1990774 tumor necrosis factor formation tumor necrosis factor anabolism GO:0042533 tumor necrosis factor biosynthesis tumor necrosis factor superfamily cytokine production